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T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
PLAC1 (placenta-specific 1) is a gene that is placenta specific and transcribed very little, if at all, in any somatic tissue. It is nevertheless expressed in many cancer cell lines. To understand how cancer cells may activate the gene in nonexpressing cells, we found that a model is provided by cla...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816221/ https://www.ncbi.nlm.nih.gov/pubmed/23999628 http://dx.doi.org/10.1038/oncsis.2013.31 |