T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts

PLAC1 (placenta-specific 1) is a gene that is placenta specific and transcribed very little, if at all, in any somatic tissue. It is nevertheless expressed in many cancer cell lines. To understand how cancer cells may activate the gene in nonexpressing cells, we found that a model is provided by cla...

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Detalles Bibliográficos
Autores principales: Chen, Y, Schlessinger, D, Nagaraja, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816221/
https://www.ncbi.nlm.nih.gov/pubmed/23999628
http://dx.doi.org/10.1038/oncsis.2013.31
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author Chen, Y
Schlessinger, D
Nagaraja, R
author_facet Chen, Y
Schlessinger, D
Nagaraja, R
author_sort Chen, Y
collection PubMed
description PLAC1 (placenta-specific 1) is a gene that is placenta specific and transcribed very little, if at all, in any somatic tissue. It is nevertheless expressed in many cancer cell lines. To understand how cancer cells may activate the gene in nonexpressing cells, we found that a model is provided by classical transformation of normal fibroblasts by SV40 T antigen. T antigen derepressed the PLAC1 P1 promoter, with Tp53 and RB exerting critical and opposing actions and nuclear receptors, retinoid X receptor and  liver X receptor, sharply increasing the level of expression.
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spelling pubmed-38162212013-11-04 T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts Chen, Y Schlessinger, D Nagaraja, R Oncogenesis Original Article PLAC1 (placenta-specific 1) is a gene that is placenta specific and transcribed very little, if at all, in any somatic tissue. It is nevertheless expressed in many cancer cell lines. To understand how cancer cells may activate the gene in nonexpressing cells, we found that a model is provided by classical transformation of normal fibroblasts by SV40 T antigen. T antigen derepressed the PLAC1 P1 promoter, with Tp53 and RB exerting critical and opposing actions and nuclear receptors, retinoid X receptor and  liver X receptor, sharply increasing the level of expression. Nature Publishing Group 2013-09 2013-09-02 /pmc/articles/PMC3816221/ /pubmed/23999628 http://dx.doi.org/10.1038/oncsis.2013.31 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Chen, Y
Schlessinger, D
Nagaraja, R
T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title_full T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title_fullStr T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title_full_unstemmed T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title_short T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
title_sort t antigen transformation reveals tp53/rb-dependent route to plac1 transcription activation in primary fibroblasts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816221/
https://www.ncbi.nlm.nih.gov/pubmed/23999628
http://dx.doi.org/10.1038/oncsis.2013.31
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