P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model

The blood–brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the sealing of vascular endothelial cells together with tight junction proteins to prevent paracellular diffusion. In addition, the BBB has a high deg...

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Detalles Bibliográficos
Autores principales: Adkins, Chris E., Mittapalli, Rajendar K., Manda, Vamshi K., Nounou, Mohamed I., Mohammad, Afroz S., Terrell, Tori B., Bohn, Kaci A., Yasemin, Celik, Grothe, Tiffany R., Lockman, Julie A., Lockman, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816283/
https://www.ncbi.nlm.nih.gov/pubmed/24312053
http://dx.doi.org/10.3389/fphar.2013.00136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816283/
https://www.ncbi.nlm.nih.gov/pubmed/24312053
http://dx.doi.org/10.3389/fphar.2013.00136

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