Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model

Spinocerebellar ataxia type 7 (SCA7) is caused by a toxic polyglutamine (polyQ) expansion in the N-terminus of the protein ataxin-7. Ataxin-7 has a known function in the histone acetylase complex, Spt/Ada/Gcn5 acetylase (STAGA) chromatin-remodeling complex. We hypothesized that some histone deacetyl...

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Detalles Bibliográficos
Autores principales: Duncan, Carlotta E, An, Mahru C, Papanikolaou, Theodora, Rugani, Caitlin, Vitelli, Cathy, Ellerby, Lisa M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816305/
https://www.ncbi.nlm.nih.gov/pubmed/24160175
http://dx.doi.org/10.1186/1750-1326-8-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816305/
https://www.ncbi.nlm.nih.gov/pubmed/24160175
http://dx.doi.org/10.1186/1750-1326-8-42

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