Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry

We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino oligonucleotides (PMOs) by alkyne functionalization of peptides, subsequent conjugation to PMOs and labelling with a fluorescent compound (Cy5-azide). Two peptide–PMO (PPMO) examples ar...

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Detalles Bibliográficos
Autores principales: Shabanpoor, Fazel, Gait, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816334/
https://www.ncbi.nlm.nih.gov/pubmed/24064913
http://dx.doi.org/10.1039/c3cc46067c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816334/
https://www.ncbi.nlm.nih.gov/pubmed/24064913
http://dx.doi.org/10.1039/c3cc46067c

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