Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease

BACKGROUND: Monogenic gain-of-function protein aggregation diseases, including Huntington’s disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotox...

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Detalles Bibliográficos
Autores principales: Gidalevitz, Tali, Wang, Ning, Deravaj, Tanuja, Alexander-Floyd, Jasmine, Morimoto, Richard I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816611/
https://www.ncbi.nlm.nih.gov/pubmed/24079614
http://dx.doi.org/10.1186/1741-7007-11-100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816611/
https://www.ncbi.nlm.nih.gov/pubmed/24079614
http://dx.doi.org/10.1186/1741-7007-11-100

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