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Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease
BACKGROUND: Monogenic gain-of-function protein aggregation diseases, including Huntington’s disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotox...
Autores principales: | Gidalevitz, Tali, Wang, Ning, Deravaj, Tanuja, Alexander-Floyd, Jasmine, Morimoto, Richard I |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816611/ https://www.ncbi.nlm.nih.gov/pubmed/24079614 http://dx.doi.org/10.1186/1741-7007-11-100 |
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