Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges

Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells. In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis. However, they often remain trapped inside endocytic organelles and fail to reach the cytosolic space of cells efficiently....

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Detalles Bibliográficos
Autores principales: Erazo-Oliveras, Alfredo, Muthukrishnan, Nandhini, Baker, Ryan, Wang, Ting-Yi, Pellois, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816665/
https://www.ncbi.nlm.nih.gov/pubmed/24223492
http://dx.doi.org/10.3390/ph5111177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816665/
https://www.ncbi.nlm.nih.gov/pubmed/24223492
http://dx.doi.org/10.3390/ph5111177

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