A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells

A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA...

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Detalles Bibliográficos
Autores principales: Cacciatore, Ivana, Fornasari, Erika, Baldassarre, Leonardo, Cornacchia, Catia, Fulle, Stefania, Di Filippo, Ester Sara, Pietrangelo, Tiziana, Pinnen, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816678/
https://www.ncbi.nlm.nih.gov/pubmed/24275787
http://dx.doi.org/10.3390/ph6010054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816678/
https://www.ncbi.nlm.nih.gov/pubmed/24275787
http://dx.doi.org/10.3390/ph6010054

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