A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells

A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA...

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Autores principales: Cacciatore, Ivana, Fornasari, Erika, Baldassarre, Leonardo, Cornacchia, Catia, Fulle, Stefania, Di Filippo, Ester Sara, Pietrangelo, Tiziana, Pinnen, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816678/
https://www.ncbi.nlm.nih.gov/pubmed/24275787
http://dx.doi.org/10.3390/ph6010054
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author Cacciatore, Ivana
Fornasari, Erika
Baldassarre, Leonardo
Cornacchia, Catia
Fulle, Stefania
Di Filippo, Ester Sara
Pietrangelo, Tiziana
Pinnen, Francesco
author_facet Cacciatore, Ivana
Fornasari, Erika
Baldassarre, Leonardo
Cornacchia, Catia
Fulle, Stefania
Di Filippo, Ester Sara
Pietrangelo, Tiziana
Pinnen, Francesco
author_sort Cacciatore, Ivana
collection PubMed
description A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H(2)O(2) on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H(2)O(2)- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
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spelling pubmed-38166782013-11-14 A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells Cacciatore, Ivana Fornasari, Erika Baldassarre, Leonardo Cornacchia, Catia Fulle, Stefania Di Filippo, Ester Sara Pietrangelo, Tiziana Pinnen, Francesco Pharmaceuticals (Basel) Article A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H(2)O(2) on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H(2)O(2)- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations. MDPI 2013-01-07 /pmc/articles/PMC3816678/ /pubmed/24275787 http://dx.doi.org/10.3390/ph6010054 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cacciatore, Ivana
Fornasari, Erika
Baldassarre, Leonardo
Cornacchia, Catia
Fulle, Stefania
Di Filippo, Ester Sara
Pietrangelo, Tiziana
Pinnen, Francesco
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title_full A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title_fullStr A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title_full_unstemmed A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title_short A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
title_sort potent (r)-alpha-bis-lipoyl derivative containing 8-hydroxyquinoline scaffold: synthesis and biological evaluation of its neuroprotective capabilities in sh-sy5y human neuroblastoma cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816678/
https://www.ncbi.nlm.nih.gov/pubmed/24275787
http://dx.doi.org/10.3390/ph6010054
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