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Stability of Recombinant Tissue Plasminogen Activator at −30 °C Over One Year

Recombinant tissue plasminogen activator (rt-PA) is used to restore patency and avoid inadvertent removal of peripheral and central venous catheters. rt-PA was reconstituted (1 mg/mL) then cryopreserved at −30 °C for 1, 2, 3, 6, 8, and 12 months and, then its stability was determined. After cryopres...

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Detalles Bibliográficos
Autor principal: Alkatheri, Abdulmalik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816680/
https://www.ncbi.nlm.nih.gov/pubmed/24275785
http://dx.doi.org/10.3390/ph6010025