Characterization of N-Linked Glycosylation in a Monoclonal Antibody Produced in NS0 Cells Using Capillary Electrophoresis with Laser-Induced Fluorescence Detection

The N-linked glycosylation in recombinant monoclonal antibodies (mAb) occurs at Asn297 on the Fc region in the CH(2) domain. Glycosylation heterogeneities have been well documented to affect biological activities such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytoto...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamm, Melissa, Wang, Yang, Rustandi, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816692/
https://www.ncbi.nlm.nih.gov/pubmed/24276024
http://dx.doi.org/10.3390/ph6030393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816692/
https://www.ncbi.nlm.nih.gov/pubmed/24276024
http://dx.doi.org/10.3390/ph6030393

Ejemplares similares