Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques

Farnesyltransferase enzyme (FTase) is considered an essential enzyme in the Ras signaling pathway associated with cancer. Thus, designing inhibitors for this enzyme might lead to the discovery of compounds with effective anticancer activity. In an attempt to obtain effective FTase inhibitors, pharma...

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Detalles Bibliográficos
Autores principales: Al-Balas, Qosay A., Amawi, Haneen A., Hassan, Mohammad A., Qandil, Amjad M., Almaaytah, Ammar M., Mhaidat, Nizar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816728/
https://www.ncbi.nlm.nih.gov/pubmed/24276257
http://dx.doi.org/10.3390/ph6060700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816728/
https://www.ncbi.nlm.nih.gov/pubmed/24276257
http://dx.doi.org/10.3390/ph6060700

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