Disruption of Smad4 Expression in T Cells Leads to IgA Nephropathy-Like Manifestations

The link between glomerular IgA nephropathy (IgAN) and T helper 2 (Th2) response has been implicated, however, the mechanisms are poorly defined because of the lack of an appropriate model. Here we report a novel murine model characterized by lineage-restricted deletion of the gene encoding MAD homo...

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Detalles Bibliográficos
Autores principales: Inoshita, Hiroyuki, Kim, Byung-Gyu, Yamashita, Michifumi, Choi, Sung Hee, Tomino, Yasuhiko, Letterio, John J., Emancipator, Steven N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817077/
https://www.ncbi.nlm.nih.gov/pubmed/24223846
http://dx.doi.org/10.1371/journal.pone.0078736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817077/
https://www.ncbi.nlm.nih.gov/pubmed/24223846
http://dx.doi.org/10.1371/journal.pone.0078736

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