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Disruption of Smad4 Expression in T Cells Leads to IgA Nephropathy-Like Manifestations
The link between glomerular IgA nephropathy (IgAN) and T helper 2 (Th2) response has been implicated, however, the mechanisms are poorly defined because of the lack of an appropriate model. Here we report a novel murine model characterized by lineage-restricted deletion of the gene encoding MAD homo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817077/ https://www.ncbi.nlm.nih.gov/pubmed/24223846 http://dx.doi.org/10.1371/journal.pone.0078736 |