Proteasomal Degradation of Mcl-1 by Maritoclax Induces Apoptosis and Enhances the Efficacy of ABT-737 in Melanoma Cells

BACKGROUND AND PURPOSE: Metastatic melanoma remains one of the most invasive and highly drug resistant cancers. The over expression of anti-apoptotic protein Mcl-1 has been associated with inferior survival, poor prognosis and chemoresistance of malignant melanoma. A BH3 mimetic, ABT-737, has demons...

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Detalles Bibliográficos
Autores principales: Pandey, Manoj K., Gowda, Krishne, Doi, Kenichiro, Sharma, Arun K., Wang, Hong-Gang, Amin, Shantu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817219/
https://www.ncbi.nlm.nih.gov/pubmed/24223823
http://dx.doi.org/10.1371/journal.pone.0078570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817219/
https://www.ncbi.nlm.nih.gov/pubmed/24223823
http://dx.doi.org/10.1371/journal.pone.0078570

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