A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target g...

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Autores principales: Moon, Yeonsook, Horsman, Douglas E., Humphries, R. Keith, Park, Gyeongsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817305/
https://www.ncbi.nlm.nih.gov/pubmed/24198749
http://dx.doi.org/10.4110/in.2013.13.5.222
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author Moon, Yeonsook
Horsman, Douglas E.
Humphries, R. Keith
Park, Gyeongsin
author_facet Moon, Yeonsook
Horsman, Douglas E.
Humphries, R. Keith
Park, Gyeongsin
author_sort Moon, Yeonsook
collection PubMed
description Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.
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spelling pubmed-38173052013-11-06 A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22) Moon, Yeonsook Horsman, Douglas E. Humphries, R. Keith Park, Gyeongsin Immune Netw Case Report Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization. The Korean Association of Immunologists 2013-10 2013-10-26 /pmc/articles/PMC3817305/ /pubmed/24198749 http://dx.doi.org/10.4110/in.2013.13.5.222 Text en Copyright © 2013 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Moon, Yeonsook
Horsman, Douglas E.
Humphries, R. Keith
Park, Gyeongsin
A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title_full A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title_fullStr A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title_full_unstemmed A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title_short A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
title_sort novel translocation involving runx1 and hoxa gene clusters in a case of acute myeloid leukemia with t(7;21)(p15;q22)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817305/
https://www.ncbi.nlm.nih.gov/pubmed/24198749
http://dx.doi.org/10.4110/in.2013.13.5.222
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