Cargando…
ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes
OBJECTIVE: The objective of this study was to determine whether ER stress correlates with β-cell dysfunction in obesity-associated diabetes. METHODS: Quantitative RT-PCR and western blot analysis were used to investigate changes in the expression of markers of ER stress, the unfolded protein respons...
Autores principales: | Omikorede, O, Qi, C, Gorman, T, Chapman, P, Yu, A, Smith, D M, Herbert, T P |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817349/ https://www.ncbi.nlm.nih.gov/pubmed/24145577 http://dx.doi.org/10.1038/nutd.2013.35 |
Ejemplares similares
-
Unique Arrangement of α- and β-Cells in Human Islets of Langerhans
por: Bosco, Domenico, et al.
Publicado: (2010) -
The Cells of the Islets of Langerhans
por: Da Silva Xavier, Gabriela
Publicado: (2018) -
Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets
por: Azzarello, Fabio, et al.
Publicado: (2022) -
Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells
por: Adams, Melissa T., et al.
Publicado: (2018) -
PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells
por: Moore, Claire E., et al.
Publicado: (2011)