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Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach
A new approach to the total synthesis of (−)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817515/ https://www.ncbi.nlm.nih.gov/pubmed/24204417 http://dx.doi.org/10.3762/bjoc.9.242 |