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Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients

Bipolar disorder (BD) is associated with abnormal circadian rhythms. In treatment responsive BD patients, lithium (Li) stabilizes mood and reduces suicide risk. Li also affects circadian rhythms and expression of ‘clock genes' that control them. However, the extent to which BD, Li and the circa...

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Detalles Bibliográficos
Autores principales: McCarthy, M J, Wei, H, Marnoy, Z, Darvish, R M, McPhie, D L, Cohen, B M, Welsh, D K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818008/
https://www.ncbi.nlm.nih.gov/pubmed/24150227
http://dx.doi.org/10.1038/tp.2013.90