Cargando…

Elevated Klotho Promoter Methylation Is Associated with Severity of Chronic Kidney Disease

Klotho (KL) expression is down-regulated in the renal tissues of chronic kidney disease (CKD) animal models and patients with end-stage renal disease. The putative role of KL promoter hypermethylation in the progression of CKD remains unclear. The present study aimed to determine renal and periphera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jing, Zhang, Xiaoyan, Zhang, Han, Lin, Jing, Zhang, Chen, Wu, Qing, Ding, Xiaoqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818221/ https://www.ncbi.nlm.nih.gov/pubmed/24224012 http://dx.doi.org/10.1371/journal.pone.0079856

Ejemplares similares

Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
por: Chen, Jing, et al.
Publicado: (2016)

Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression
por: Chen, Jing, et al.
Publicado: (2017)

The role of klotho in chronic kidney disease
por: Zou, Di, et al.
Publicado: (2018)

Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization
por: Lv, Jing, et al.
Publicado: (2020)

The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene
por: Aczel, Dora, et al.
Publicado: (2023)

Klotho, Aging, and the Failing Kidney
por: Buchanan, Sarah, et al.
Publicado: (2020)

Correction for: Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization
por: Lv, Jing, et al.
Publicado: (2023)

Soluble α-Klotho Serum Levels in Chronic Kidney Disease
por: Rotondi, Silverio, et al.
Publicado: (2015)

The controversy of klotho as a potential biomarker in chronic kidney disease
por: Yu, Li-Xia, et al.
Publicado: (2022)

Klotho promoter methylation status and its prognostic value in ovarian cancer
por: Al-Zahrani, Maryam H., et al.
Publicado: (2021)

Is Klotho deficiency independently associated with cardiovascular risk in chronic kidney disease?
por: Bae, Eun Hui
Publicado: (2016)

Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease
por: Park, Yoo Jin, et al.
Publicado: (2018)

Investigation on urinary and serum alpha klotho in dogs with chronic kidney disease
por: Yi, Hong jae, et al.
Publicado: (2020)

α-Klotho, Plasma Asymmetric Dimethylarginine, and Kidney Disease Progression
por: Qian, Jing, et al.
Publicado: (2021)

Klotho在肺癌中的研究进展
por: WANG, Jing, et al.
Publicado: (2023)

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats
por: Cheng, Meng-Fu, et al.
Publicado: (2010)

Necrostatin-1 Attenuates Cisplatin-Induced Nephrotoxicity Through Suppression of Apoptosis and Oxidative Stress and Retains Klotho Expression
por: Ning, Yichun, et al.
Publicado: (2018)

Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury
por: Seo, Min Young, et al.
Publicado: (2015)

Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease
por: Saar-Kovrov, Valeria, et al.
Publicado: (2021)

Effects of chronic kidney disease on cognitive function and α-klotho expression in hippocampus
por: Huang, Menglan, et al.
Publicado: (2022)

Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice
por: Lin, Wenjun, et al.
Publicado: (2017)

The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease
por: Chen, Yan, et al.
Publicado: (2021)

Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression
por: Li, Huihui, et al.
Publicado: (2019)

Klotho Ameliorates Vascular Calcification via Promoting Autophagy
por: Li, Lufeng, et al.
Publicado: (2022)

DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma
por: Zhu, Yun, et al.
Publicado: (2019)

Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy
por: Chen, Xinxin, et al.
Publicado: (2018)

Association of High-Density Lipoprotein Subclasses with Chronic Kidney Disease Progression, Atherosclerosis, and Klotho
por: Kanda, Eiichiro, et al.
Publicado: (2016)

α-klotho and anemia in patients with chronic kidney disease patients: A new perspective
por: Xu, Yang, et al.
Publicado: (2017)

SIRT1 and Klotho expression in the heart and kidneys of rats with acute and chronic renovascular hypertension
por: Yeganeh-Hajahmadi, Mahboobeh, et al.
Publicado: (2021)

Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality
por: Hu, Jiachang, et al.
Publicado: (2017)

Klotho, the elusive kidney-derived anti-ageing factor
por: Sanchez-Niño, Maria Dolores, et al.
Publicado: (2019)

Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Indoxyl sulfate and high-density lipoprotein cholesterol in early stages of chronic kidney disease
por: Wang, Li, et al.
Publicado: (2020)

Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid and aorta of uremic rats
por: Ritter, Cynthia S., et al.
Publicado: (2015)

Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014
por: Zhang, Jialing, et al.
Publicado: (2023)

Klotho as a potential predictor of deceased donor kidney transplantation outcomes
por: Kim, Suh Min, et al.
Publicado: (2020)

Association of 'Klotho' gene polymorphism with cerebral infarction
por: Li, Yu, et al.
Publicado: (2022)

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
por: Akimoto, Tetsu, et al.
Publicado: (2012)

Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations
por: Adema, Aaltje Y., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_la6hqr2vvn6pa3occcgh8rpi8u