Isoaspartate Accumulation in Mouse Brain Is Associated with Altered Patterns of Protein Phosphorylation and Acetylation, Some of Which Are Highly Sex-Dependent

Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT). Mice deficient in PIMT accumulate isoAsp-containing proteins, resulting in cognitive deficits, abnormal neuronal physiology and cytoarch...

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Detalles Bibliográficos
Autores principales: Qin, Zhenxia, Kaufman, Rachel S., Khoury, Rana N., Khoury, Mitri K., Aswad, Dana W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818261/
https://www.ncbi.nlm.nih.gov/pubmed/24224061
http://dx.doi.org/10.1371/journal.pone.0080758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818261/
https://www.ncbi.nlm.nih.gov/pubmed/24224061
http://dx.doi.org/10.1371/journal.pone.0080758

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