A Single Nucleotide Polymorphism in cBIM Is Associated with a Slower Achievement of Major Molecular Response in Chronic Myeloid Leukaemia Treated with Imatinib

PURPOSE: BIM is essential for the response to tyrosine-kinase inhibitors (TKI) in chronic myeloid leukaemia (CML) patients. Recently, a deletion polymorphism in intron 2 of the BIM gene was demonstrated to confer an intrinsic TKI resistance in Asian patients. The present study aimed at identifying m...

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Detalles Bibliográficos
Autores principales: Augis, Vanessa, Airiau, Kelly, Josselin, Marina, Turcq, Béatrice, Mahon, François-Xavier, Belloc, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818406/
https://www.ncbi.nlm.nih.gov/pubmed/24223824
http://dx.doi.org/10.1371/journal.pone.0078582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818406/
https://www.ncbi.nlm.nih.gov/pubmed/24223824
http://dx.doi.org/10.1371/journal.pone.0078582

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