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Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and n...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818444/ https://www.ncbi.nlm.nih.gov/pubmed/24118853 http://dx.doi.org/10.1186/1471-2261-13-85 |
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author | Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik Cronberg, Tobias |
author_facet | Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik Cronberg, Tobias |
author_sort | Lilja, Gisela |
collection | PubMed |
description | BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial investigating cognitive dysfunction and its consequences for patients’ and relatives’ daily life. METHODS/DESIGN: Sub-study sites in five European countries included surviving TTM patients 180 days after cardiac arrest. In addition to the instruments for neurological function used in the main trial, sub-study patients were specifically tested for difficulties with memory (Rivermead Behavioural Memory Test), attention (Symbol Digit Modalities Test) and executive function (Frontal Assessment Battery). Cognitive impairments will be related to the patients’ degree of participation in society (Mayo-Portland Adaptability Inventory-4), health related quality of life (Short Form Questionnaire–36v2©), and the caregivers’ situation (Zarit Burden Interview©). The two intervention groups (33°C and 36°C) will be compared with a group of myocardial infarction controls. DISCUSSION: This large international sub-study of a randomized controlled trial will focus on mild to moderate cognitive impairment and its consequences for cardiac arrest survivors and their caregivers. By using an additional battery of tests we may be able to detect more subtle differences in cognitive function between the two intervention groups than identified in the main study. The results of the study could be used to develop a relevant screening model for cognitive dysfunction after cardiac arrest. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01946932. |
format | Online Article Text |
id | pubmed-3818444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38184442013-11-07 Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik Cronberg, Tobias BMC Cardiovasc Disord Study Protocol BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial investigating cognitive dysfunction and its consequences for patients’ and relatives’ daily life. METHODS/DESIGN: Sub-study sites in five European countries included surviving TTM patients 180 days after cardiac arrest. In addition to the instruments for neurological function used in the main trial, sub-study patients were specifically tested for difficulties with memory (Rivermead Behavioural Memory Test), attention (Symbol Digit Modalities Test) and executive function (Frontal Assessment Battery). Cognitive impairments will be related to the patients’ degree of participation in society (Mayo-Portland Adaptability Inventory-4), health related quality of life (Short Form Questionnaire–36v2©), and the caregivers’ situation (Zarit Burden Interview©). The two intervention groups (33°C and 36°C) will be compared with a group of myocardial infarction controls. DISCUSSION: This large international sub-study of a randomized controlled trial will focus on mild to moderate cognitive impairment and its consequences for cardiac arrest survivors and their caregivers. By using an additional battery of tests we may be able to detect more subtle differences in cognitive function between the two intervention groups than identified in the main study. The results of the study could be used to develop a relevant screening model for cognitive dysfunction after cardiac arrest. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01946932. BioMed Central 2013-10-12 /pmc/articles/PMC3818444/ /pubmed/24118853 http://dx.doi.org/10.1186/1471-2261-13-85 Text en Copyright © 2013 Lilja et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Study Protocol Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik Cronberg, Tobias Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title | Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title_full | Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title_fullStr | Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title_full_unstemmed | Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title_short | Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial |
title_sort | cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the target temperature management trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818444/ https://www.ncbi.nlm.nih.gov/pubmed/24118853 http://dx.doi.org/10.1186/1471-2261-13-85 |
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