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Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial

BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and n...

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Autores principales: Lilja, Gisela, Nielsen, Niklas, Friberg, Hans, Horn, Janneke, Kjaergaard, Jesper, Pellis, Tommaso, Rundgren, Malin, Wetterslev, Jørn, Wise, Matt P, Nilsson, Fredrik, Cronberg, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818444/
https://www.ncbi.nlm.nih.gov/pubmed/24118853
http://dx.doi.org/10.1186/1471-2261-13-85
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author Lilja, Gisela
Nielsen, Niklas
Friberg, Hans
Horn, Janneke
Kjaergaard, Jesper
Pellis, Tommaso
Rundgren, Malin
Wetterslev, Jørn
Wise, Matt P
Nilsson, Fredrik
Cronberg, Tobias
author_facet Lilja, Gisela
Nielsen, Niklas
Friberg, Hans
Horn, Janneke
Kjaergaard, Jesper
Pellis, Tommaso
Rundgren, Malin
Wetterslev, Jørn
Wise, Matt P
Nilsson, Fredrik
Cronberg, Tobias
author_sort Lilja, Gisela
collection PubMed
description BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial investigating cognitive dysfunction and its consequences for patients’ and relatives’ daily life. METHODS/DESIGN: Sub-study sites in five European countries included surviving TTM patients 180 days after cardiac arrest. In addition to the instruments for neurological function used in the main trial, sub-study patients were specifically tested for difficulties with memory (Rivermead Behavioural Memory Test), attention (Symbol Digit Modalities Test) and executive function (Frontal Assessment Battery). Cognitive impairments will be related to the patients’ degree of participation in society (Mayo-Portland Adaptability Inventory-4), health related quality of life (Short Form Questionnaire–36v2©), and the caregivers’ situation (Zarit Burden Interview©). The two intervention groups (33°C and 36°C) will be compared with a group of myocardial infarction controls. DISCUSSION: This large international sub-study of a randomized controlled trial will focus on mild to moderate cognitive impairment and its consequences for cardiac arrest survivors and their caregivers. By using an additional battery of tests we may be able to detect more subtle differences in cognitive function between the two intervention groups than identified in the main study. The results of the study could be used to develop a relevant screening model for cognitive dysfunction after cardiac arrest. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01946932.
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spelling pubmed-38184442013-11-07 Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial Lilja, Gisela Nielsen, Niklas Friberg, Hans Horn, Janneke Kjaergaard, Jesper Pellis, Tommaso Rundgren, Malin Wetterslev, Jørn Wise, Matt P Nilsson, Fredrik Cronberg, Tobias BMC Cardiovasc Disord Study Protocol BACKGROUND: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial investigating cognitive dysfunction and its consequences for patients’ and relatives’ daily life. METHODS/DESIGN: Sub-study sites in five European countries included surviving TTM patients 180 days after cardiac arrest. In addition to the instruments for neurological function used in the main trial, sub-study patients were specifically tested for difficulties with memory (Rivermead Behavioural Memory Test), attention (Symbol Digit Modalities Test) and executive function (Frontal Assessment Battery). Cognitive impairments will be related to the patients’ degree of participation in society (Mayo-Portland Adaptability Inventory-4), health related quality of life (Short Form Questionnaire–36v2©), and the caregivers’ situation (Zarit Burden Interview©). The two intervention groups (33°C and 36°C) will be compared with a group of myocardial infarction controls. DISCUSSION: This large international sub-study of a randomized controlled trial will focus on mild to moderate cognitive impairment and its consequences for cardiac arrest survivors and their caregivers. By using an additional battery of tests we may be able to detect more subtle differences in cognitive function between the two intervention groups than identified in the main study. The results of the study could be used to develop a relevant screening model for cognitive dysfunction after cardiac arrest. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01946932. BioMed Central 2013-10-12 /pmc/articles/PMC3818444/ /pubmed/24118853 http://dx.doi.org/10.1186/1471-2261-13-85 Text en Copyright © 2013 Lilja et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Lilja, Gisela
Nielsen, Niklas
Friberg, Hans
Horn, Janneke
Kjaergaard, Jesper
Pellis, Tommaso
Rundgren, Malin
Wetterslev, Jørn
Wise, Matt P
Nilsson, Fredrik
Cronberg, Tobias
Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title_full Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title_fullStr Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title_full_unstemmed Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title_short Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial
title_sort cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the target temperature management trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818444/
https://www.ncbi.nlm.nih.gov/pubmed/24118853
http://dx.doi.org/10.1186/1471-2261-13-85
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