Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation

We observed in a previous study (PLoS ONE 6:e24522) that the self-regulation of amygdala activity via real-time fMRI neurofeedback (rtfMRI-nf) with positive emotion induction was associated, in healthy participants, with an enhancement in the functional connectivity between the left amygdala (LA) an...

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Autores principales: Zotev, Vadim, Phillips, Raquel, Young, Kymberly D., Drevets, Wayne C., Bodurka, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819266/
https://www.ncbi.nlm.nih.gov/pubmed/24223175
http://dx.doi.org/10.1371/journal.pone.0079184
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author Zotev, Vadim
Phillips, Raquel
Young, Kymberly D.
Drevets, Wayne C.
Bodurka, Jerzy
author_facet Zotev, Vadim
Phillips, Raquel
Young, Kymberly D.
Drevets, Wayne C.
Bodurka, Jerzy
author_sort Zotev, Vadim
collection PubMed
description We observed in a previous study (PLoS ONE 6:e24522) that the self-regulation of amygdala activity via real-time fMRI neurofeedback (rtfMRI-nf) with positive emotion induction was associated, in healthy participants, with an enhancement in the functional connectivity between the left amygdala (LA) and six regions of the prefrontal cortex. These regions included the left rostral anterior cingulate cortex (rACC), bilateral dorsomedial prefrontal cortex (DMPFC), bilateral superior frontal gyrus (SFG), and right medial frontopolar cortex (MFPC). Together with the LA, these six prefrontal regions thus formed the functional neuroanatomical network engaged during the rtfMRI-nf procedure. Here we perform a structural vector autoregression (SVAR) analysis of the effective connectivity for this network. The SVAR analysis demonstrates that the left rACC plays an important role during the rtfMRI-nf training, modulating the LA and the other network regions. According to the analysis, the rtfMRI-nf training leads to a significant enhancement in the time-lagged effect of the left rACC on the LA, potentially consistent with the ipsilateral distribution of the monosynaptic projections between these regions. The training is also accompanied by significant increases in the instantaneous (contemporaneous) effects of the left rACC on four other regions – the bilateral DMPFC, the right MFPC, and the left SFG. The instantaneous effects of the LA on the bilateral DMPFC are also significantly enhanced. Our results are consistent with a broad literature supporting the role of the rACC in emotion processing and regulation. Our exploratory analysis provides, for the first time, insights into the causal relationships within the network of regions engaged during the rtfMRI-nf procedure targeting the amygdala. It suggests that the rACC may constitute a promising target for rtfMRI-nf training along with the amygdala in patients with affective disorders, particularly posttraumatic stress disorder (PTSD).
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spelling pubmed-38192662013-11-12 Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation Zotev, Vadim Phillips, Raquel Young, Kymberly D. Drevets, Wayne C. Bodurka, Jerzy PLoS One Research Article We observed in a previous study (PLoS ONE 6:e24522) that the self-regulation of amygdala activity via real-time fMRI neurofeedback (rtfMRI-nf) with positive emotion induction was associated, in healthy participants, with an enhancement in the functional connectivity between the left amygdala (LA) and six regions of the prefrontal cortex. These regions included the left rostral anterior cingulate cortex (rACC), bilateral dorsomedial prefrontal cortex (DMPFC), bilateral superior frontal gyrus (SFG), and right medial frontopolar cortex (MFPC). Together with the LA, these six prefrontal regions thus formed the functional neuroanatomical network engaged during the rtfMRI-nf procedure. Here we perform a structural vector autoregression (SVAR) analysis of the effective connectivity for this network. The SVAR analysis demonstrates that the left rACC plays an important role during the rtfMRI-nf training, modulating the LA and the other network regions. According to the analysis, the rtfMRI-nf training leads to a significant enhancement in the time-lagged effect of the left rACC on the LA, potentially consistent with the ipsilateral distribution of the monosynaptic projections between these regions. The training is also accompanied by significant increases in the instantaneous (contemporaneous) effects of the left rACC on four other regions – the bilateral DMPFC, the right MFPC, and the left SFG. The instantaneous effects of the LA on the bilateral DMPFC are also significantly enhanced. Our results are consistent with a broad literature supporting the role of the rACC in emotion processing and regulation. Our exploratory analysis provides, for the first time, insights into the causal relationships within the network of regions engaged during the rtfMRI-nf procedure targeting the amygdala. It suggests that the rACC may constitute a promising target for rtfMRI-nf training along with the amygdala in patients with affective disorders, particularly posttraumatic stress disorder (PTSD). Public Library of Science 2013-11-06 /pmc/articles/PMC3819266/ /pubmed/24223175 http://dx.doi.org/10.1371/journal.pone.0079184 Text en © 2013 Zotev et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zotev, Vadim
Phillips, Raquel
Young, Kymberly D.
Drevets, Wayne C.
Bodurka, Jerzy
Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title_full Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title_fullStr Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title_full_unstemmed Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title_short Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation
title_sort prefrontal control of the amygdala during real-time fmri neurofeedback training of emotion regulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819266/
https://www.ncbi.nlm.nih.gov/pubmed/24223175
http://dx.doi.org/10.1371/journal.pone.0079184
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