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ADAM17-Mediated Processing of TNF-α Expressed by Antiviral Effector CD8(+) T Cells Is Required for Severe T-Cell-Mediated Lung Injury
Influenza infection in humans evokes a potent CD8(+) T-cell response, which is important for clearance of the virus but may also exacerbate pulmonary pathology. We have previously shown in mice that CD8(+) T-cell expression of TNF-α is required for severe and lethal lung injury following recognition...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819268/ https://www.ncbi.nlm.nih.gov/pubmed/24223177 http://dx.doi.org/10.1371/journal.pone.0079340 |