Determining the Binding Affinity of Therapeutic Monoclonal Antibodies towards Their Native Unpurified Antigens in Human Serum

Monoclonal antibodies (mAbs) are a growing segment of therapeutics, yet their in vitro characterization remains challenging. While it is essential that a therapeutic mAb recognizes the native, physiologically occurring epitope, the generation and selection of mAbs often rely on the use of purified r...

Descripción completa

Detalles Bibliográficos
Autores principales: Bee, Christine, Abdiche, Yasmina N., Pons, Jaume, Rajpal, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819287/
https://www.ncbi.nlm.nih.gov/pubmed/24223227
http://dx.doi.org/10.1371/journal.pone.0080501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819287/
https://www.ncbi.nlm.nih.gov/pubmed/24223227
http://dx.doi.org/10.1371/journal.pone.0080501

Ejemplares similares