An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development

APC normally down-regulates WNT signaling in human colon, and APC mutations cause proliferative abnormalities in premalignant crypts leading to colon cancer, but the mechanisms are unclear at the level of spatial and functional organization of the crypt. Accordingly, we postulated a counter-current-...

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Detalles Bibliográficos
Autores principales: Boman, Bruce M., Fields, Jeremy Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819610/
https://www.ncbi.nlm.nih.gov/pubmed/24224156
http://dx.doi.org/10.3389/fonc.2013.00244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819610/
https://www.ncbi.nlm.nih.gov/pubmed/24224156
http://dx.doi.org/10.3389/fonc.2013.00244

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