A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contribution of these two disease mechanisms is a major challeng...

Descripción completa

Detalles Bibliográficos
Autores principales: Gualeni, Benedetta, Rajpar, M. Helen, Kellogg, Aaron, Bell, Peter A., Arvan, Peter, Boot-Handford, Raymond P., Briggs, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820264/
https://www.ncbi.nlm.nih.gov/pubmed/24046357
http://dx.doi.org/10.1242/dmm.013342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820264/
https://www.ncbi.nlm.nih.gov/pubmed/24046357
http://dx.doi.org/10.1242/dmm.013342

Ejemplares similares