Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

In mice, induced global disruption of the Ptpn11 gene, which encodes the SHP-2 tyrosine phosphatase, results in severe skeletal abnormalities. To understand the extent to which skeletal abnormalities can be attributed to perturbation of SHP-2 function in bone-forming osteoblasts and chondrocytes, we...

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Detalles Bibliográficos
Autores principales: Lapinski, Philip E., Meyer, Melissa F., Feng, Gen-Sheng, Kamiya, Nobuhiro, King, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820267/
https://www.ncbi.nlm.nih.gov/pubmed/24077964
http://dx.doi.org/10.1242/dmm.012849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820267/
https://www.ncbi.nlm.nih.gov/pubmed/24077964
http://dx.doi.org/10.1242/dmm.012849

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