Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

Numerous mouse models have utilized Cre-loxP technology to modify gene expression. Adverse effects of Cre recombinase activity have been reported, including in the heart. However, the mechanisms associated with cardiac Cre toxicity are largely unknown. Here, we show that expression of Cre in cardiom...

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Detalles Bibliográficos
Autores principales: Bersell, Kevin, Choudhury, Sangita, Mollova, Mariya, Polizzotti, Brian D., Ganapathy, Balakrishnan, Walsh, Stuart, Wadugu, Brian, Arab, Shima, Kühn, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820268/
https://www.ncbi.nlm.nih.gov/pubmed/23929941
http://dx.doi.org/10.1242/dmm.010447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820268/
https://www.ncbi.nlm.nih.gov/pubmed/23929941
http://dx.doi.org/10.1242/dmm.010447

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