A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)

PRDM14 functions in embryonic stem cell (ESC) maintenance to promote the expression of pluripotency-associated genes while suppressing differentiation genes. Expression of PRDM14 is tightly regulated and typically limited to ESCs and primordial germ cells; however, aberrant expression is associated...

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Detalles Bibliográficos
Autores principales: Carofino, Brandi L., Ayanga, Bernard, Justice, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820272/
https://www.ncbi.nlm.nih.gov/pubmed/24046360
http://dx.doi.org/10.1242/dmm.012575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820272/
https://www.ncbi.nlm.nih.gov/pubmed/24046360
http://dx.doi.org/10.1242/dmm.012575

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