Cargando…

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)

PRDM14 functions in embryonic stem cell (ESC) maintenance to promote the expression of pluripotency-associated genes while suppressing differentiation genes. Expression of PRDM14 is tightly regulated and typically limited to ESCs and primordial germ cells; however, aberrant expression is associated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carofino, Brandi L., Ayanga, Bernard, Justice, Monica J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2013
Materias:	Resource Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820272/ https://www.ncbi.nlm.nih.gov/pubmed/24046360 http://dx.doi.org/10.1242/dmm.012575

Ejemplares similares

Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors
por: Dettman, E.J., et al.
Publicado: (2011)

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
por: Carofino, Brandi L., et al.
Publicado: (2016)

Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL
por: Simko, Stephen J., et al.
Publicado: (2012)

The Zinc Finger SET Domain Gene Prdm14 Is Overexpressed in Lymphoblastic Lymphomas with Retroviral Insertions at Evi32
por: Dettman, E. J., et al.
Publicado: (2008)

Acute lymphoblastic leukemia displays a distinct highly methylated genome
por: Hetzel, Sara, et al.
Publicado: (2022)

PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
por: Moriya, Chiharu, et al.
Publicado: (2018)

Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping
por: Strassman, Alexander, et al.
Publicado: (2017)

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation
por: Gell, Joanna J., et al.
Publicado: (2018)

Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway
por: Zhou, Pan, et al.
Publicado: (2019)

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia
por: Passaro, Diana, et al.
Publicado: (2021)

Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4
por: Zheng, Honglan, et al.
Publicado: (2022)

Rapid Inactivation of Proteins by Rapamycin-Induced Rerouting to Mitochondria
por: Robinson, Margaret S., et al.
Publicado: (2010)

Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification
por: Zerjatke, Thomas, et al.
Publicado: (2017)

Deep Learning Neural Networks Highly Predict Very Early Onset of Pluripotent Stem Cell Differentiation
por: Waisman, Ariel, et al.
Publicado: (2019)

A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines
por: Liang, Liming, et al.
Publicado: (2013)

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
por: Tzelepis, Konstantinos, et al.
Publicado: (2016)

Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression
por: Dharmadhikari, Avinash V., et al.
Publicado: (2016)

Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion
por: Gura Sadovsky, Rotem, et al.
Publicado: (2017)

DisCVR: Rapid viral diagnosis from high-throughput sequencing data
por: Maabar, Maha, et al.
Publicado: (2019)

Pericardial Relapse of Acute Lymphoblastic Leukemia (ALL)
por: Maslov, Diana V., et al.
Publicado: (2021)

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
por: Kiskinis, Evangelos, et al.
Publicado: (2018)

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
por: Kauts, Mari-Liis, et al.
Publicado: (2018)

FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs
por: CONSOLARO, FRANCESCA, et al.
Publicado: (2015)

CoVizu: Rapid analysis and visualization of the global diversity of SARS-CoV-2 genomes
por: Ferreira, Roux-Cil, et al.
Publicado: (2021)

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines
por: Schmid-Burgk, Jonathan L., et al.
Publicado: (2014)

Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications
por: Cairns, Dana M., et al.
Publicado: (2016)

One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice
por: Lin, Ying‐Cing, et al.
Publicado: (2018)

Overexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia
por: Organista-Nava, Jorge, et al.
Publicado: (2018)

Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA
por: Brok-Volchanskaya, Vera S., et al.
Publicado: (2019)

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
por: Di Zazzo, Erika, et al.
Publicado: (2023)

Multiple marker abundance profiling: combining selected reaction monitoring and data‐dependent acquisition for rapid estimation of organelle abundance in subcellular samples
por: Hooper, Cornelia M., et al.
Publicado: (2017)

Sensitivity to Pain in Children With Acute Lymphoblastic Leukemia (ALL)
por: Firoozi, Manijeh, et al.
Publicado: (2012)

A Rapid and Efficient 2D/3D Nuclear Segmentation Method for Analysis of Early Mouse Embryo and Stem Cell Image Data
por: Lou, Xinghua, et al.
Publicado: (2014)

PRDM12 in Health and Diseases
por: Rienzo, Monica, et al.
Publicado: (2021)

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
por: Huang, Jessie, et al.
Publicado: (2020)

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
por: Fajardo, Val A., et al.
Publicado: (2015)

SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia
por: Dong, Song, et al.
Publicado: (2015)

Identification and Characterization of a PRDM14 Homolog in Japanese Flounder (Paralichthys olivaceus)
por: Fan, Lin, et al.
Publicado: (2015)

PRDM14 Is a Unique Epigenetic Regulator Stabilizing Transcriptional Networks for Pluripotency
por: Seki, Yoshiyuki
Publicado: (2018)

Mutations increased overexpression of Notch1 in T-cell acute lymphoblastic leukemia
por: Lin, Chunlan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_v1f0oqc3a6pbjdp1ec38dq9bek