CYP2A6 Genotype but not Age Determines Cotinine Half-life in Infants and Children

The formation of cotinine, the main proximate metabolite and a biomarker of nicotine exposure, is mediated primarily by CYP2A6. Our aim was to determine if higher cotinine levels in young children exposed to secondhand smoke (SHS) are a result of age-related differences in pharmacokinetics. Forty-ni...

Descripción completa

Detalles Bibliográficos
Autores principales: Dempseyl, Delia A., Sambol, Nancy C., Jacob, Peyton, Hoffmann, E., Tyndale, Rachel F., Fuentes-Afflick, Elena, Benowitz, Neal L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820275/
https://www.ncbi.nlm.nih.gov/pubmed/23714690
http://dx.doi.org/10.1038/clpt.2013.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820275/
https://www.ncbi.nlm.nih.gov/pubmed/23714690
http://dx.doi.org/10.1038/clpt.2013.114

Ejemplares similares