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Characterization of Prostate Cancer Bone Metastases According to Expression Levels of Steroidogenic Enzymes and Androgen Receptor Splice Variants

BACKGROUND: Intra-tumoral steroidogenesis and constitutive androgen receptor (AR) activity have been associated with castration-resistant prostate cancer (CRPC). This study aimed to examine if CRPC bone metastases expressed higher levels of steroid-converting enzymes than untreated bone metastases....

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Detalles Bibliográficos
Autores principales: Jernberg, Emma, Thysell, Elin, Bovinder Ylitalo, Erik, Rudolfsson, Stina, Crnalic, Sead, Widmark, Anders, Bergh, Anders, Wikström, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820691/
https://www.ncbi.nlm.nih.gov/pubmed/24244276
http://dx.doi.org/10.1371/journal.pone.0077407