Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity

Chronic viral infections lead to CD8(+) T cell exhaustion, characterized by impaired cytokine secretion. Presence of the immune-regulatory cytokine IL-10 promotes chronicity of Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 infection, while absence of IL-10/IL-10R signaling early during infectio...

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Detalles Bibliográficos
Autores principales: Richter, Kirsten, Perriard, Guillaume, Behrendt, Rayk, Schwendener, Reto A., Sexl, Veronika, Dunn, Robert, Kamanaka, Masahito, Flavell, Richard A., Roers, Axel, Oxenius, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820745/
https://www.ncbi.nlm.nih.gov/pubmed/24244162
http://dx.doi.org/10.1371/journal.ppat.1003735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820745/
https://www.ncbi.nlm.nih.gov/pubmed/24244162
http://dx.doi.org/10.1371/journal.ppat.1003735

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