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Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity()

The peptide hormone apelin is translated as a 77-residue preproprotein, truncated to the 55-residue proapelin and, subsequently, to 13–36-residue bioactive isoforms named apelin-13 to -36. Proapelin is hypothesized to be cleaved to apelin-36 and then to the shorter isoforms. However, neither the mec...

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Detalles Bibliográficos
Autores principales: Shin, Kyungsoo, Pandey, Aditya, Liu, Xiang-Qin, Anini, Younes, Rainey, Jan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821026/
https://www.ncbi.nlm.nih.gov/pubmed/24251091
http://dx.doi.org/10.1016/j.fob.2013.08.001