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Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821079/ https://www.ncbi.nlm.nih.gov/pubmed/24222802 http://dx.doi.org/10.2174/1874104501307010023 |
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author | Matsuda, Satoru Nakanishi, Atsuko Wada, Yoko Kitagishi, Yasuko |
author_facet | Matsuda, Satoru Nakanishi, Atsuko Wada, Yoko Kitagishi, Yasuko |
author_sort | Matsuda, Satoru |
collection | PubMed |
description | Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development. |
format | Online Article Text |
id | pubmed-3821079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-38210792013-11-11 Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy Matsuda, Satoru Nakanishi, Atsuko Wada, Yoko Kitagishi, Yasuko Open Med Chem J Article Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development. Bentham Open 2013-10-31 /pmc/articles/PMC3821079/ /pubmed/24222802 http://dx.doi.org/10.2174/1874104501307010023 Text en © Matsuda et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Matsuda, Satoru Nakanishi, Atsuko Wada, Yoko Kitagishi, Yasuko Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title_full | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title_fullStr | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title_full_unstemmed | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title_short | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy |
title_sort | roles of pi3k/akt/pten pathway as a target for pharmaceutical therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821079/ https://www.ncbi.nlm.nih.gov/pubmed/24222802 http://dx.doi.org/10.2174/1874104501307010023 |
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