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Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy

Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as...

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Detalles Bibliográficos
Autores principales: Matsuda, Satoru, Nakanishi, Atsuko, Wada, Yoko, Kitagishi, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821079/
https://www.ncbi.nlm.nih.gov/pubmed/24222802
http://dx.doi.org/10.2174/1874104501307010023
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author Matsuda, Satoru
Nakanishi, Atsuko
Wada, Yoko
Kitagishi, Yasuko
author_facet Matsuda, Satoru
Nakanishi, Atsuko
Wada, Yoko
Kitagishi, Yasuko
author_sort Matsuda, Satoru
collection PubMed
description Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development.
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spelling pubmed-38210792013-11-11 Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy Matsuda, Satoru Nakanishi, Atsuko Wada, Yoko Kitagishi, Yasuko Open Med Chem J Article Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development. Bentham Open 2013-10-31 /pmc/articles/PMC3821079/ /pubmed/24222802 http://dx.doi.org/10.2174/1874104501307010023 Text en © Matsuda et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Matsuda, Satoru
Nakanishi, Atsuko
Wada, Yoko
Kitagishi, Yasuko
Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title_full Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title_fullStr Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title_full_unstemmed Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title_short Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
title_sort roles of pi3k/akt/pten pathway as a target for pharmaceutical therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821079/
https://www.ncbi.nlm.nih.gov/pubmed/24222802
http://dx.doi.org/10.2174/1874104501307010023
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