Development of a Peptide-Derived Orally-Active Kappa-Opioid Receptor Agonist Targeting Peripheral Pain

Kappa-opioid agonists are particularly efficacious in the treatment of peripheral pain but suffer from central nervous system (CNS)-mediated effects that limit their development. One promising kappa-agonist is the peptidic compound CR665. Although not orally available, CR665 given i.v. exhibits high...

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Detalles Bibliográficos
Autores principales: Hughes, Jr, Francis M., Shaner, Brooke E., Brower, Justin O., Woods, R. Jeremy, Dix, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821081/
https://www.ncbi.nlm.nih.gov/pubmed/24222801
http://dx.doi.org/10.2174/1874104501307010016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821081/
https://www.ncbi.nlm.nih.gov/pubmed/24222801
http://dx.doi.org/10.2174/1874104501307010016

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