A DPYD variant (Y186C) in individuals of African ancestry associated with reduced DPD enzyme activity

5-fluorouracil (5-FU) is used to treat many aggressive cancers, such as those of the colon, breast, and head & neck. The responses to 5-FU, both toxicity and efficacy, vary between racial groups, potentially due to variability in enzyme activity of dihydropyrimidine dehydrogenase (DPD, encoded b...

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Detalles Bibliográficos
Autores principales: Offer, Steven M., Lee, Adam M., Mattison, Lori K., Fossum, Croix, Wegner, Natalie J., Diasio, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821392/
https://www.ncbi.nlm.nih.gov/pubmed/23588312
http://dx.doi.org/10.1038/clpt.2013.69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821392/
https://www.ncbi.nlm.nih.gov/pubmed/23588312
http://dx.doi.org/10.1038/clpt.2013.69

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