Investigations of the Binding of [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II) to DNA via Various Cross-Linking Modes

We have constructed models for a series of platinum-DNA adducts that represent the binding of two agents, [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II), to DNA via inter- and intra-strand cross-linking, and carried out molecular dynamics simulations and DNA conformational dynamics calculations....

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Detalles Bibliográficos
Autores principales: Yue, Hongwei, Yang, Bo, Wang, Yan, Chen, Guangju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821573/
https://www.ncbi.nlm.nih.gov/pubmed/24077126
http://dx.doi.org/10.3390/ijms141019556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821573/
https://www.ncbi.nlm.nih.gov/pubmed/24077126
http://dx.doi.org/10.3390/ijms141019556

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