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Investigations of the Binding of [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II) to DNA via Various Cross-Linking Modes
We have constructed models for a series of platinum-DNA adducts that represent the binding of two agents, [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II), to DNA via inter- and intra-strand cross-linking, and carried out molecular dynamics simulations and DNA conformational dynamics calculations....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821573/ https://www.ncbi.nlm.nih.gov/pubmed/24077126 http://dx.doi.org/10.3390/ijms141019556 |