Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein stability, contributes to c-Myc protein reduction under acidosis. The pH-sen...

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Detalles Bibliográficos
Autores principales: Li, Zhigang, Dong, Lixue, Dean, Eric, Yang, Li V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821613/
https://www.ncbi.nlm.nih.gov/pubmed/24152439
http://dx.doi.org/10.3390/ijms141020236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821613/
https://www.ncbi.nlm.nih.gov/pubmed/24152439
http://dx.doi.org/10.3390/ijms141020236

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