Cargando…

Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein stability, contributes to c-Myc protein reduction under acidosis. The pH-sen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhigang, Dong, Lixue, Dean, Eric, Yang, Li V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821613/ https://www.ncbi.nlm.nih.gov/pubmed/24152439 http://dx.doi.org/10.3390/ijms141020236

Ejemplares similares

The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction
por: Nagasaka, Akiomi, et al.
Publicado: (2017)

Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury
por: Tsurumaki, Hiroaki, et al.
Publicado: (2015)

The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
por: Sato, Koichi, et al.
Publicado: (2020)

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
por: Justus, Calvin R., et al.
Publicado: (2017)

Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
por: Dong, Lixue, et al.
Publicado: (2013)

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
por: Tcymbarevich, Irina V., et al.
Publicado: (2019)

TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice
por: Dai, Shih-Ping, et al.
Publicado: (2017)

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
por: Justus, Calvin R., et al.
Publicado: (2013)

Developments in Burkitt’s lymphoma: novel cooperations in oncogenic MYC signaling
por: Spender, Lindsay C, et al.
Publicado: (2014)

TDAG51 deficiency attenuates dextran sulfate sodium-induced colitis in mice
por: Jeon, Hyoeun, et al.
Publicado: (2022)

TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis
por: Hsieh, Wei-Shan, et al.
Publicado: (2017)

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas
por: Tran, Phuoc T., et al.
Publicado: (2008)

Increased frequency of the S allele of the L-myc oncogene in non-Hodgkin's lymphoma.
por: Crossen, P. E., et al.
Publicado: (1994)

Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition
por: Poole, Candace J., et al.
Publicado: (2018)

OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation
por: Perren, Leonie, et al.
Publicado: (2023)

The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer
por: Jing, Zhibin, et al.
Publicado: (2016)

RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC
por: Selvarajan, V, et al.
Publicado: (2017)

MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis
por: Xu, Xiyuan, et al.
Publicado: (2022)

TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition
por: Yun, Hyeongseok, et al.
Publicado: (2019)

Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin‐1 Expression
por: Hossain, Gazi S., et al.
Publicado: (2013)

Sensing acidosis: nociception or sngception?
por: Lin, Jiann-Her, et al.
Publicado: (2018)

Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain
por: Chen, Ying-Ju, et al.
Publicado: (2009)

Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma
por: Lin, Yun Hsiao, et al.
Publicado: (2021)

Gut Mucosal Microbiome Is Perturbed in Rheumatoid Arthritis Mice and Partly Restored after TDAG8 Deficiency or Suppression by Salicylanilide Derivative
por: Nguyen, Ngoc Tuan, et al.
Publicado: (2022)

Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis
por: Basseri, Sana, et al.
Publicado: (2013)

Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors
por: Klatt, Wybke, et al.
Publicado: (2020)

Oncogenic MYC amplifies mitotic perturbations
por: Littler, Samantha, et al.
Publicado: (2019)

TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway
por: Wu, Xiaozhi, et al.
Publicado: (2023)

The distribution of the c-myc oncogene product in malignant lymphomas and various normal tissues as demonstrated by immunocytochemistry.
por: Jack, A. S., et al.
Publicado: (1986)

Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma
por: Garcia-Reyero, Julia, et al.
Publicado: (2020)

TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain
por: Dai, Shih-Ping, et al.
Publicado: (2020)

Coamplification of the L‐myc and N‐myc Oncogenes in a Neuroblastoma Cell Line
por: Jinbo, Takeshi, et al.
Publicado: (1989)

TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation
por: Oberst, Michael D, et al.
Publicado: (2008)

TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease
por: Carlisle, Rachel E., et al.
Publicado: (2021)

Oncogene addiction to c-MYC in myeloma cells
por: Holien, Toril, et al.
Publicado: (2012)

Myc, Oncogenic Protein Translation, and the Role of Polyamines
por: Flynn, Andrea T., et al.
Publicado: (2018)

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein
por: Lechable, Marion, et al.
Publicado: (2023)

TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts
por: Park, Eui-Soon, et al.
Publicado: (2013)

Another explanation for decreased oxygen consumption in lactic acidosis
por: Rosival, Viktor
Publicado: (2010)

Detection of the c-myc oncogene product in testicular cancer.
por: Sikora, K., et al.
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_1ftb0pb4mstn22ar0697uoleug