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Modulation of a Protein Free-Energy Landscape by Circular Permutation
[Image: see text] Circular permutations usually retain the native structure and function of a protein while inevitably perturbing its folding dynamics. By using simulations with a structure-based model and a rigorous methodology to determine free-energy surfaces from trajectories, we evaluate the ef...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821731/ https://www.ncbi.nlm.nih.gov/pubmed/24090448 http://dx.doi.org/10.1021/jp406818t |