Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice

Treatment with trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of Human Epidermal Growth Factor Receptor 2 (HER2), very successfully improves outcomes for women with HER2-positive breast cancer. However, trastuzumab treatment was recently linked to potentially...

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Detalles Bibliográficos
Autores principales: ElZarrad, M. Khair, Mukhopadhyay, Partha, Mohan, Nishant, Hao, Enkui, Dokmanovic, Milos, Hirsch, Dianne S., Shen, Yi, Pacher, Pal, Wu, Wen Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821852/
https://www.ncbi.nlm.nih.gov/pubmed/24255707
http://dx.doi.org/10.1371/journal.pone.0079543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821852/
https://www.ncbi.nlm.nih.gov/pubmed/24255707
http://dx.doi.org/10.1371/journal.pone.0079543

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