Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody

G protein-coupled receptors (GPCRs) are integral membrane proteins that play an essential role in human physiology, yet the molecular processes through which they bind to their endogenous agonists and activate effector proteins remain poorly understood. Thus far, it has not been possible to capture...

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Detalles Bibliográficos
Autores principales: Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C., Enos, Michael D., Weis, William I., Garcia, K. Christopher, Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822040/
https://www.ncbi.nlm.nih.gov/pubmed/24056936
http://dx.doi.org/10.1038/nature12572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822040/
https://www.ncbi.nlm.nih.gov/pubmed/24056936
http://dx.doi.org/10.1038/nature12572

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