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Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease
Mutations in presenilins (PS1 and PS2) account for the vast majority of early onset familial Alzheimer's disease cases. Beside the well investigated role of presenilins as the catalytic unit in γ-secretase complex, their involvement in regulation of intracellular calcium homeostasis has recentl...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822592/ https://www.ncbi.nlm.nih.gov/pubmed/23379308 http://dx.doi.org/10.1111/jcmm.12008 |