Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

Vascular dysfunction is emerging as a key pathological hallmark in Alzheimer’s disease (AD). A leaky blood–brain barrier (BBB) has been described in AD patient tissue and in vivo AD mouse models. Brain endothelial cells (BECs) are linked together by tight junctional (TJ) proteins, which are a key de...

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Detalles Bibliográficos
Autores principales: Tai, L M, Holloway, K A, Male, D K, Loughlin, A J, Romero, I A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822747/
https://www.ncbi.nlm.nih.gov/pubmed/19438816
http://dx.doi.org/10.1111/j.1582-4934.2009.00717.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822747/
https://www.ncbi.nlm.nih.gov/pubmed/19438816
http://dx.doi.org/10.1111/j.1582-4934.2009.00717.x

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