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Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives

Aberrant telomere homeostasis is essential for cell immortality, enabling cells to evade telomere dependent senescence. Disruption of telomere structure and function in cancer cells is highly toxic as shown by detailed pre-clinical evaluation of telomerase inhibitors. Under telomerase inhibition, ce...

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Detalles Bibliográficos
Autores principales: Bilsland, Alan E, Cairney, Claire J, Nicol Keith, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822786/
https://www.ncbi.nlm.nih.gov/pubmed/21199331
http://dx.doi.org/10.1111/j.1582-4934.2010.01253.x

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